Individuals who are suffering with psychological disorders or the family who are supporting them may sometimes have thoughts how psychotherapy or cognitive behaviour therapy change the brain and how far the significant and evident results in such cases...... The recent advances in neuro-imaging techniques have helped to increase the understanding of the neuronal correlates of mental disorders. Psychological interventions can promote changes in the thoughts, feelings, and behaviours of patients. Can we then say that the psychological treatment promotes brain changes? Unfortunately, the biological mechanisms related to psychotherapy are little known. On the other hand, the arrival of neuro-imaging techniques makes it possible to investigate the neurobiological consequences of psychological treatment. Cognitive behavioral therapy (CBT) proposes to treat various mental disorders. The literature has reported that CBT has treatment models with high efficacy rates. ...